Natural History of Atrial septal defect

Natural History of Atrial septal defect


Natural History of Atrial septal defect

What is the most common presentation for undetected ASD with a significant shunt (Qp/Qs > 1.5/1.0) ?


[A] Chest pain
[B] Effort dyspnea
[C] Atrial fibrillation
[D] Paradoxical embolism



Natural History of Atrial septal defect


  • [Qp/Qs] > 2.0/1.0 – Large true secundum ASDs – Managed in childhood by surgical or device closure
  • Qp/Qs > 1.5/1.0 – If remain as undetected ASD – presents as Effort angina
    • Effort angina – 30% of patients present by the third decade and more than 75% of patients present by the fifth decade
    • Supraventricular arrhythmias (atrial fibrillation or flutter)
    • Right-sided heart failure – develop by 40 years of age
    • Paradoxical embolism -TIA

[Qp/Qs] = Pulmonary artery blood flow relative to systemic blood flow

Natural History of Atrial septal defect


  • Most common presenting symptoms in adults are – exertional dyspnea

Natural History of Atrial septal defect