Ventricular myocytes nucleus
Ventricular myocytes nucleus
Ventricular myocytes nucleus
Ventricular myocytes nucleus typically
[A] Mononucleate
[B] Binucleate
[C] Quadrinucleate
[D] Multinucleate
Ventricular myocytes are typically binucleate
Some smaller or more juvenile myocytes have one nucleus and some up to three to four nuclei.
Conversion of cardiomyocytes from a mononucleate to binucleate phenotype –
- Binucleation is a characteristic of terminally differentiated cells that are unable to proliferate, whereas mononucleate cells continue to cycle.
- Early in normal fetal development the majority of cardiomyocytes are mononucleate, allowing growth to be achieved by proliferation.
- In the timeframe surrounding birth, heart maturation occurs where mononucleate cells begin the transition to a binucleate phenotype.
